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Name Cardiolipin IgG ELISA kit
Price $550.00
Category NameAutoimmune Disease kits
MethodELISA: Enzyme Linked Immunosorbent Assay
PrincipleELISA - Indirect;Antigen Coated Plate
Detection RangeSemi-Quantitative: Positive, Negative and Cut-off
Sample10ul serum
Total Time~60min
Shelf Life12 months from the manufacturing date

Item #:                    1491-2   Quantity:               



Cardiolipin IgG ELISA Test kit

Cardiolipin IgG ELISA Test kit Intended Use
Cardiolipin Antibody Test kit is an enzymelinked immunosorbent assay (ELISA) designed for the semi-quantitative measurement of circulating IgG autoantibodies to cardiolipin

Kit Components:
• Microplate: 96 wells coated with Cardiolipin antigen
• Peroxidase Conjugated goat anti-human IgG (Fc chain specific)
• Positive Control (Human Serum)
• Calibrator (Human Serum)
• Negative Control (Human Serum)
• Cardiolipin IgG Test Kit Sample Diluent
• TMB Substrate Solution
• Stop Solution (1M H2SO4, 0.7M HCL)
• Wash Buffer Concentrate (10X)

Method Principle
This Diagnostic Automation/ Cortez Diagnostics Inc. Human Cardiolipin IgG ELISA Test kit is designed to detect IgG class antibodies to Cardiolipin in human sera. Wells of plastic microwell strips are sensitized by passive absorption with Cardiolipin antigen. The test procedure involves three incubation steps. For further details please refer to complete instructions manual supplied with the product.

Background Information
Cardiolipin auto antibodies (ACA) or anti cardiolipin (aCL) are frequently found in patients with systemic lupus erythematosus (SLE) as in patients with other autoimmune diseases, and in some individuals with no apparent chronic illnesses. Elevated levels of ACA/aCL have been reported to be significantly associated with the presence of both venous and arterial thrombosis, thrombocytopenia, and recurrent fetal loss. Anti-phospholipid syndrome has been used to describe patients who present these clinical manifestations, in association with ACA or lupus anticoagulant. ACAs are found in the immunoglobulin classes IgG, IgM and IgA. IgG antibodies will be found in progressive stages of manifested autoimmune disorders, whereas IgM antibodies are a valuable indicator in the diagnosis of beginning autoimmune disease. ACA IgG shows a good correlation to the clinical status of the patient in thrombosis, thrombocytopenia, fetal loss, and some neurological disorders. ACA IgA is often associated with IgG antibodies. ACA IgA seems to have a greater validity in thrombosis and fetal loss. ELISA testing for ACAs of various isotypes aids in diagnosis of anti-phospholipid syndrome in patients with SLE and lupus-like disorders.

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